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J Biol Chem. 2015 Jun 26;290(26):15909-20. doi: 10.1074/jbc.M115.640136. Epub 2015 May 5. Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors. Kalinowska M1, Chávez AE1, Lutzu S1, Castillo PE1, Bukauskas FF1, Francesconi A2.

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Choudhuri K, Llodrá J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML. Nature. 2014 Mar 6;507(7490):118-23.

Actin foci facilitate activation of the phospholipase C- in primary T lymphocytes via the WASP pathway. Kumari S, Depoil D, Martinelli R, Judokusumo E, Carmona G, Gertler FB, Kam LC, Carman CV, Burkhardt JK, Irvine DJ, Dustin ML. Elife. 2015 Mar 11;4.

Zonapse research is in its scientific infancy.
There are new assays waiting to be developed.
There are new processes waiting to be studied.
There are new ideas waiting to be tested.
There are even old ideas waiting to be tested.

(excerpts from Biology Direct 1:37, 2006)

"The striking similarities in molecular, structural, and functional features between the tight junction and the synapse suggest that epithelial cells may utilize the same proteins that neurons use for synaptic transmission to perform a similar function."

"The presence of zonapse at the apical domain would allow cells to communicate through secretion of transmitters within the confined extracellular space delineated by the tight junction membrane barrier, which could directly stimulate or inhibit activity of neighbouring cells."

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