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Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK. Nat Cell Biol. 2017

Interplay between tight junctions & adherens junctions. Exp Cell Res. 2017

Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity. Nat Commun. 2017

Zonapse research is in its scientific infancy.
There are new assays waiting to be developed.
There are new processes waiting to be studied.
There are new ideas waiting to be tested.
There are even old ideas waiting to be tested.
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(excerpts from Biology Direct 1:37, 2006)

"The striking similarities in molecular, structural, and functional features between the tight junction and the synapse suggest that epithelial cells may utilize the same proteins that neurons use for synaptic transmission to perform a similar function."

"The presence of zonapse at the apical domain would allow cells to communicate through secretion of transmitters within the confined extracellular space delineated by the tight junction membrane barrier, which could directly stimulate or inhibit activity of neighbouring cells."

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